Protein Details: P2X purinoceptor 7
Protein ID
ICDB_Pro_1731
Protein Name
P2X purinoceptor 7
Gene Name
P2rx7; P2x7
Organism
Mus musculus (Mouse)
Length
595 amino acids
AlphaFoldDB
AF-Q9Z1M0-F1-model_v4.pdb
Function
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand; ATP; functions as a scavenger receptor in the recognition and engulfment of apoptotic cells.
Sequence
MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCGNCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEATNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1016/s0014-5793(98)01332-5; 10.1371/journal.pbio.1000112; 10.1096/fj.07-9294com; 10.1038/nbt.1532; 10.1016/j.cell.2010.12.001
RefSeq
NP_035157.2